Tools and infrastructure for open, non-equilibrium systems.
We model systems where the environmental coupling is the dynamics — drugs binding to receptors, organizations keeping commitments, light propagating through a photonic chip. Equilibrium-based tools struggle in these regimes. Pleco's work is about the careful application of non-equilibrium methods to specific substrate domains.
Learn more →What we work on
Pleco Kineτics
Drug-target binding kinetics. Curated datasets and physics-grounded ML for predicting selectivity in domains where the literature has rich mechanism and thermodynamic coverage but kinetic measurements are sparse.
Active research: carbonic anhydrase isoform selectivity. Methodology paper in progress.
Pleco Kineτics →
Promise Pipeline
Fragility mapping for organizational infrastructure. Implements Promise Theory (Burgess) on commitment networks. AGPL-3.0 open source.
github.com/koda-wzkp/promise-engine →Pleco Photonics
Photonic computing architecture for parallel simulation of open quantum systems. USPTO provisional filed April 2026.
Hardware in development.
Pleco Photonics →How we work
- Mechanism first. Each substrate gets its own Phase 1 literature work before any modeling.
- Pre-registered. Methodology, training data, and acceptance criteria locked before evaluation. Honest negative results when they happen.
- Curation as contribution. Most of what we sell is the careful work upstream of prediction.
Contact
Research collaborations, methodology consulting, early-access interest: